Science: Eating a tiny bit of mom’s poop could give C-section babies an immune ‘primer’ - Africa Green Magazine

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Science: Eating a tiny bit of mom’s poop could give C-section babies an immune ‘primer’


Science: Eating a tiny bit of mom’s poop could give C-section babies an immune ‘primer’

The bacteria that live in our bodies, particularly our guts, play key roles in immunity and development. But babies born by cesarean section don’t get the rich blend of microbes that come from a vaginal birth—microbes that may help prevent disorders such as asthma and allergies. Now, a study suggests feeding these infants a small amount of their mothers’ feces could “normalize” their gut microbiome—the ecosystem of bacteria, viruses, and fungi in the digestive system—and possibly give their immune systems a healthier start.

Newborns’ guts are blank slates: Babies born vaginally get microbes from their mother’s perineum (the area around the vulva and anus), and those born by C-section get them from mom’s skin. Within just a few hours, the differences are stark. For example, Bacteroides and Bifidobacteria bacteria are abundant in the guts of babies born vaginally, but “almost absent in C-section babies,” says Willem de Vos, a microbiome scientist at the University of Helsinki. Because babies born by C-section have higher rates of immune-related disorders later in life, researchers think this early-life bacteria could “prime” the immune system during a critical development period.

To lessen the damage, previous studies have “seeded” C-section babies with their mothers’ vaginal microbiota. But when those efforts didn’t seem to do the trick, de Vos and colleagues theorized that vaginally born babies might get their microbes from accidentally ingesting a smidgen of their mother’s stool during the birthing process. So they recruited 17 mothers preparing to give birth via C-section. Three weeks before the women were to give birth, their fecal samples were scanned for pathogens including group B Streptococcus and herpesvirus.

Seven women had pathogen-free samples. After they gave birth, the researchers mixed 3.5 or 7 milligrams of their diluted fecal matter into 5 milliliters of breast milk—donated from a breast milk bank and pumped from the mothers themselves—and then fed it to their babies.

Next, the scientists analyzed the babies’ gut microbiomes by sequencing genetic material in their feces. They started with the very first bowel movement, known as the meconium, and continued sampling at regular intervals over 12 weeks. When they compared the microbiomes with those of 29 babies born vaginally and 18 born by C-section without fecal transplants, they found the treated babies’ microbiota evolved to resemble those of vaginally born babies within 3 weeks, they report today in Cell. Typically, it takes a full year for this transition to happen.

Like babies born vaginally, treated infants had abundant colonies of Bacteroidales within days. And compared with untreated C-section babies, the treated infants had significantly fewer pathogenic bacteria, such as Enterococcus faecium and Salmonella enterica. The infants didn’t experience any adverse effects during the study period, de Vos says.

The study supports the idea that the “collateral impact” of a cesarean delivery could be mitigated, says Maria Gloria Dominguez-Bello, a microbiologist at Rutgers University, New Brunswick. “There’s a reason the orifice for having babies is next to the anal orifice, in all vertebrates,” she says. “This is natural selection, not random. And it’s a clear message from nature telling us, ‘We want the newborns to be exposed to feces.’”

Knowing how much feces to expose them to is critical, however, adds John Penders, a medical microbiologist at Maastricht University. “We don’t know how much babies ingest naturally, so getting the right dose requires careful testing.” Longer studies with more infants should ensure the dose is safe, he says.

De Vos and his colleagues have already started such a study: a randomized, controlled trial in which dozens of C-section babies receive either feces from their mothers or a placebo. The researchers plan to monitor the babies’ health over several years, he says. In the meantime, de Vos cautions that fecal transplants require careful medical management. “This is not something parents should be doing at home.”




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